Month: February 2009

Cancers in hiv

From 99 til 07 infection related cancers like anal have decreased slightly but are still a lot higher in incidence than in HIV hegatives. Liver, oral-throat and hodgkins lyphoma have increased 2-4 percent. 20305 poz patients were followed from 99 til 2007 at kaiser permanente in California. Mostly gay white men, however.

Complications and OIs

Richard Chaisson from John Hopkins presented survival and mortality data.There is a direct relation between economic development and mortality. Haiti has the highest mortality rate in the americas and argentina, the us and canada have the lowest.Head, esophagus, anal lung and bladder cancers have increased in poz patientsFactors involved are immune defficiency, inflammation, pro coagulation …

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Vaccine Strategy

Dr richard koup reviewed where we are in vaccines. Vaxgen, the merck vaccine and the canarypox vaccines were not succesfulThree trials were stopped in 2007. The STEP trial showed that those with pre existing exposure to adenovirus ad5 had a higher infection rates on the vaccine versus placebo. Those infected were also mostly uncircumcised. Those …

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HIV infection in the brain

Dr Gonzalez also explained that immune activation may also have a worse effect on the brain than the virus itself. Activated infected monocytes penetrate the blood brain barrier .People with high LPS (lipopoly saccharides that come from a leaky gut) in their blood had higher dementia also.