As we know from several studies, insulin levels seem to be higher in HIV positives than negatives. We also have more problems with increased triglycerides, low HDL, lower bone density, increased visceral fat, and glucose intolerance/insulin resistance.
You will read some radical statements in the link below, among which this is one:
“Incidentally, two of the most popular diabetic medications today, Actos and Avandia, wrongly claimed by their manufactures as being insulin sensitizers, actually work by multiplying fat cells, thereby creating more wastebaskets in which to store sugar as fat. They actually make you fatter and more leptin resistant, and they accelerate your rate of aging”
“Elevated insulin plays an important role in osteoporosis. Insulin promotes the excretion of calcium in the urine…This is a major source of osteoporosis and far exceeds in importance a lack of calcium in the vast majority of people. There is a high correlation between osteoporosis and calcification of arteries. In other words, most people with osteoporosis have the calcium – it’s just in the wrong places.”
https://www.diabeteshealth.com/read/2008/01/13/5617.html