I am convinced this supplement works for depression and fatigue. I have taken 400 mg twice a day and can definitely feel a difference the first day. Something else that I have noticed is that my hairy leukoplakia goes away within days. It can also decrease liver enzymes. However, it is contraindicated for those with bipolar disorder. It is not cheap. I get mine from Jarrow at the Houston Buyers Club.
Here is a summary of studies
https://www.healthyplace.com/Communities/Depression/treatment/alternative/sam-e.asp
I am attaching a study done in HIV
https://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=535560