The main lipid abnormality of people living with HIV is low high density lipoprotein (HDL). There are 5 subfractions of HDL: 2a, 2b, 3a, 3b, and 3c, from largest (and most effective in cholesterol removal) to smallest (and least effective).
Neither pravastatin nor rosuvastatin changes the distribution of high-density lipoprotein (HDL) subfractions in patients who are HIV-seropositive with severe dyslipidaemia undergoing treatment with a combined antiretroviral therapy (cART) and protease inhibitor, according to substudy results presented at the 82nd European Atherosclerosis Society (EAS) Congress.
- Get aerobic exercise. Moderate to vigorous aerobic exercise can boost HDL by 5% to 10%. Aim for five 30-minute sessions per week.
- Lose weight if you need to. If you’re overweight or obese, you can boost your HDL level by about 1 mg/dL for every seven pounds lost, although any amount of weight loss will help.
- If you smoke, quit. HDL levels rise by as much as 15% to 20% after you quit.
- Eat a healthy diet. Avoid trans fats, which increase bad cholesterol and decrease good cholesterol. Avoid highly refined carbohydrates, such as white-flour products.
- Consider medications. Niacin, available over the counter, is the most effective HDL-raising medication available. Niacin can be strong medicine — work with your clinician if you want to try it. NAC is also a good supplement to consider.
- Avoid higher doses of testosterone