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HIV-associated fatigue in the era of highly active antiretroviral therapy: novel biological mechanisms?

I am convinced that our mitochondria are affected even after years off Zerit, DDI or AZT. Mitochondrial dysfunction has been widely reported with D drugs (D4T, DDI) and AZT and has been linked to lipoatrophy and metabolic problems.  But I think what we ignore is the permanent effects on the mitochondria even after years of stopping those drugs.   Although mitochondria DNA in fat and muscle …

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FDA approved Jak inhibitors and their potential use in HIV – Interview with Dr Raymond Schinazi

As part of my work as a cure and salvage treatment activist, I am constantly searching for treatment options that could serve two purposes: existing medications that could help patients with multidrug resistance and at the same time be used as an approach to cure HIV.  Since my non profit (Program for Wellness Restoration) has …

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Gilead Prices Its New STRIBILD Once a Day HIV Regimen Higher Than Complera and Atripla

Gilead has priced its STRIBILD at  $28,500 / year.  The other two single tablet HIV regimens, Complera and Atripla cost $26, 350 /year and $24,971.64/year, respectively. A regimen of twice a day raltegravir  (Isentress) plus once a day Truvada costs   $30,753 /year. Boosted Reyataz  plus Truvada  costs $34,390/year and boosted Prezista plus Truvada is …

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Could Smart Drugs Help People With Cognitive Loss?

By Lily McCann Smart drugs, also known as neuro enhancers, memory enhancers, intelligence enhancers, cognitive enhancers and nootropics, are drugs and supplements that improve functions of the brain, including attention, memory, concentration and intelligence. These mental function enhancers are believed to work by improving the brain’s oxygen supply, stimulating the growth of nerves in the …

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Is the best HIV drug bad for muscle? Isentress increases CPK

CPK is creatine phosphokinase, an enzyme found mainly in the heart, brain, and skeletal muscle. It is tested by taking a blood sample. High CPK can indicate muscle destruction, heart attacks, central nervous sysmtem issues, and others. Long term exposure of high CPK can load up your kidneys, and may cause muscle loss and weakness. …

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Starting HIV Medications Within 10 Weeks from Infection Can Create Elite Controllers After 3 Years of Treatment

Distribution of the HIV reservoir in patients spontaneously controlling HIV infection after treatment interruption Presented by Charline Bacchus (France). C. Bacchus1, L. Hocqueloux2, V. Avettand-Fenoël3, A. Saez-Cirion4, A. Mélard3, B. Descours5, A. Samri1, C. Blanc6, B. Autran1, C. Rouzioux3, VISCONTI and ALT ANRS study groups 1Cellular and Tissular Immunology Laboratory, Pierre and Marie Curie University, …

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Two more men with HIV now virus-free. Is this a cure?

They are still taking HIV medications, so we won’t know until after they interrupt their HIV treatment… Two More Patients HIV-Free After Bone Marrow Transplants https://abcnews.go.com/blogs/health/2012/07/26/two-more-patients-hiv-free-after-bone-marrow-transplants/ Two more men with HIV now virus-free. Is this a cure? https://www.msnbc.msn.com/id/48338421/ns/health-mens_health/t/two-more-men-hiv-now-virus-free-cure/#.UBG2nI6TNUR HIV Undetectable in 2 Men After Bone Marrow Transplants: Study https://health.usnews.com/health-news/news/articles/2012/07/26/hiv-undetectable-in-2-men-after-bone-marrow-transplants-study 2 HIV patients in Boston show …

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GSK is Exploring a Once a Month Injectable HIV Treatment Regimen

Pharmacokinetics, Safety and Tolerability of the HIV Integrase Inhibitor S/GSK1265744 Long Acting Parenteral Nanosuspension Following Single Dose Administration to Healthy Adults          Presented at the International AIDS Conference in Washington this week Discussion  — S/GSK1265744 long acting parenteral administration prolonged plasma levels (apparent t1/2of 2150days; Figure 4) compared with oral administration (oral …

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