Month: March 2011

Dolutegravir, Trii and new abacavir data- How it all ties together

By Nelson Vergel Powerusa.org Dr Joe Eron presented new dosing and efficacy phase 2b data on the new GSK integrase inhibitor dolutegravir (DTG, S/GSK1349572) using 50 mg twice a day in patients whose HIV virus has developed resistance to raltegravir (Isentress). Prior data presented in Vienna from a cohort (cohort 1) of patients who took …

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Zinc Fingers and Gene Therapies for HIV: Mimicking the Cured Berlin Patient?

Zinc Fingers and Gene Therapies for HIV: Mimicking the Cured Berlin Patient? By Nelson Vergel March 2, 2011 Jay Lalezari, M.D., from the University of California-San Francisco presented first-of-its-kind study data on the use of zinc finger nucleases (ZFNs) to artificially disrupt the CCR5 receptor on the surface of CD4 cells, which HIV uses to infect its …

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The FDA says abacavir (Ziagen) does not cause cardiovascular problems, opening the door for GSK to combine it with their new integrase inhibitor for naive patients

This will make it possible for GSK-ViiV to market their new Trii formulation of the new integrase inhibitor GSK572 (generic name: dolutegravir) plus Epzicom (abacavir plus epivir) as a once a day pill for naive patients It contradicts all the previous studies that said that abacavir (Ziagen) causes increased cardiovascular risks. https://www.aidsmap.com/page/1682771/ GSK is currently …

The FDA says abacavir (Ziagen) does not cause cardiovascular problems, opening the door for GSK to combine it with their new integrase inhibitor for naive patients Read More »